We aim to understand the molecular mechanisms that regulate protein biogenesis and quality control pathways with approaches utilizing biochemistry, structural biology, and cell biology. Specific interests focus on processes that occur on ribosomes and at cellular membranes.
Protein Biosynthesis and Degradation
Our lab integrates chemical and cell biologal approaches to study cell division and chromosome segregation.
Our laboratory is presently studying the regulation and mechanisms of protein breakdown in animal and bacterial cells.
We are interested in the ubiquitin-proteasome pathway and related regulatory systems. Specific topics include the mechanism of the proteasome, ubiquitin-like proteins, antizyme, and nonproteolytic functions of ubiquitination.