Our lab integrates chemical and cell biological approaches to study cell division and chromosome segregation.
Protein Biosynthesis and Degradation
We aim to understand the molecular mechanisms that regulate protein biogenesis and quality control pathways with approaches utilizing biochemistry, structural biology, and cell biology. Specific interests focus on processes that occur on ribosomes and at cellular membranes.
Our laboratory is presently studying the regulation and mechanisms of protein breakdown in animal and bacterial cells.
We are interested in the ubiquitin-proteasome pathway and related regulatory systems. Specific topics include the mechanism of the proteasome, ubiquitin-like proteins, antizyme, and nonproteolytic functions of ubiquitination.