• Thank you for a great 2017 Cell Bio Retreat!

  • Images courtesy of Talley Lambert, PhD (Cell Biology Microscopy Facility)

  • Pietro De Camilli, MD gives the 2017 Fawcett Lecture

Recent News & Achievements

Latest Research

Harper lab develops novel technique to observe ubiquitylation events - May 04, 2018

Harper lab develops novel technique to observe ubiquitylation events

Alban Ordureau, a postdoc in the Harper lab, has developed a proteomics method that allows for the dynamics of PARKIN-dependent mitochondrial ubiquitylation to be followed with unprecedented preision and in a site-specific manner. The approach employed targeted proteomics of ubiquitylation sites in 15 PARKIN targets, allowing digital snapshots of PARKIN activity. This system was used to monitor PARKIN activity in stem cell-derived cortical ...Read more >>

Kirchhausen lab develops new microscope that captures 3-D movies of cells inside living organisms - Apr 22, 2018

Kirchhausen lab develops new microscope that captures 3-D movies of cells inside living organisms
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The Kirchhausen lab, in collaboration with Nobel laureate and Janelia group leader Eric Betzig, has developed a microscope capable of capturing 3-D images and videos of cells inside living organisms in unprecedented detail. To enable such high resolution images, researchers combined two technologies: lattice light sheet ...Read more >>

Through a systematic analysis of ribophagy in mammalian cells, the Harper lab defines how ribosomes and other cytosolic proteins are eaten via autophagy in response to stress - Jan 02, 2018

Through a systematic analysis of ribophagy in mammalian cells, the Harper lab defines how ribosomes and other cytosolic proteins are eaten via autophagy in response to stress
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Ribosomes are abundant cellular machines regulated by assembly, supernumerary subunit turnover, and nascent chain quality control mechanisms. Moreover, nitrogen starvation in yeast has been reported to promote selective ribosome delivery to the vacuole in an autophagy conjugation system-dependent manner, a process called "ribophagy". However, whether ribophagy in mammals is selective or regulated has not been examined. Using Ribo-Keima flux reporters, Heeseon An from the ...Read more >>