• Images courtesy of Talley Lambert, PhD (Cell Biology Microscopy Facility)

  • Andrew Dillin, PhD, UC Berkeley, 2016-2017 Cell Biology Seminar Series 

  • Pietro De Camilli, MD gives the 2017 Fawcett Lecture

  • The Cell Biology Research Scholars Program is a Harvard University summer internship for undergraduate students with a passion for scientific discovery and fundamental biology.
    Read more and apply ...

Recent Awards & Achievements

Recent Faculty Promotion: Adrian Salic - Jul 21, 2017

Recent Faculty Promotion: Adrian Salic
Adrian Salic

Congratulations to Adrian Salic on his promotion to Professor of Cell Biology!

Adrian uses biochemistry, cell, and chemical biology to elucidate how vertebrate cells send and respond to Hedgehog signals. Two key aspects his lab is currently investigating are the activation of the secreted Hedgehog protein and the regulated proteolysis of Gli, the transcriptional effector of the Hedghog pathway.  ...Read more >>

Latest Research

Farese and Walther lab discovers triglyceride synthesis enzyme DGAT1 protects adipocytes from lipid induced ER stress during lipolysis - Aug 10, 2017

Farese and Walther lab discovers triglyceride synthesis enzyme DGAT1 protects adipocytes from lipid induced ER stress during lipolysis
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Triglyceride (TG) storage in adipose tissue provides the major reservoir for metabolic energy in mammals. During lipolysis, fatty acids (FAs) are hydrolyzed from adipocyte TG stores and transported to other tissues for fuel. For unclear reasons, a large portion of hydrolyzed FAs in adipocytes is re-esterified to TGs in a “futile”, ATP-consuming, energy dissipating cycle. The Farese & Walther lab's recent ...Read more >>

Rapoport and Liao labs determine the cryo-EM structure of the ERAD Hrd1/Hrd3 complex - Jul 19, 2017

Rapoport and Liao labs determine the cryo-EM structure of the ERAD Hrd1/Hrd3 complex
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A conserved pathway called “endoplasmic reticulum associated protein degradation (ERAD) is responsible for the disposal of misfolded ER proteins. Previous work from the Rapoport lab indicated that the multi-spanning ubiquitin ligase Hrd1 is a key component of ERAD; Hrd1 allows misfolded luminal and membrane proteins to move from the ER into the cytosol. However, it remained unclear whether Hrd1 forms a protein-conducting channel. In a paper recently published in ...Read more >>

Liao lab discovers key steps in CRISPR’s mechanism of action - Jul 06, 2017

Liao lab discovers key steps in CRISPR’s mechanism of action
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Scientists in the Liao lab and Cornell University have produced near-atomic resolution snapshots of CRISPR that reveal key steps in its mechanism of action. The findings, published in Cell on June 29, provide the structural data necessary for efforts to improve the efficiency and accuracy of CRISPR for biomedical applications. You can read more ...Read more >>