• Dr. Kelsey Martin (UCLA) speaks at Neuro-RNA Symposium 2013, organized by Cell Biology postdocs.

  • Left: Actin (green), microtubules (blue), & DNA (red) in a mouse embryonic fibroblast.  Courtesy of A. Lomakin (Danuser lab).
    Right: Endoplasmic reticulum-associated Climp63 (red) & reticulons (green) in mammalian cells.  From Shibata et al. Cell (Rapoport Lab).

  • 2013's newly-minted PhDs from Cell Bio & BBS: Rachel Davidowitz, David Rhee, Joshua Wilson-Grady, M. Rosa Ng, Sinisa Hravtin, & E. Emrah Er. 

  • Left: Larval muscle (red), neurons (green), & nuclei (blue) in Drosophila cells.  Courtesy of A. Sen (Artavanis-Tsakonas Lab).
    Middle: Membrane protein Climp63 (red) & calreticulin (green) in subdomains of the endoplasmic reticulum.  From Shibata et al. Cell (Rapoport Lab).
    Right: Close-up view of Drosophila larval muscle (red), neurons (green), & nuclei (blue).  Courtesy of A. Sen (Artavanis-Tsakonas Lab).

  • Cell Biology faculty members Anders Näär, Tom Rapoport, and John Flanagan at the annual departmental retreat, Cape Cod, Massachusetts.

  • The Neuro-RNA Symposium 2013 organizers: Cell Biology postdocs Nicolas Preitner, Jianhua Shi, Melissa Hancock, and Xinmin Li.

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Recent Awards & Achievements

News - 12/02/2014 - 8:29pm

Cell Press designates 6 papers from 5 Cell Biology faculty members as "landmark"
Finley
Harper
Shi
Spiegelman
Yuan

Cell celebrated its 40th anniversary by revisiting "landmark" Cell publications, an esteemed list that includes six papers from five  faculty members: Dan Finley, Wade Harper, Yang Shi, Bruce Spiegelman, and Junying Yuan.  One of these papers, Yang Shi's research identifying the first histone demethylase, LSD1, was also honored and showcased as an "Annotated Classic." ...Read more >>

News - 11/24/2014 - 5:50pm

Randy King recognized for his excellence in teaching
Dr. Randy King

Randy King, the Harry C. McKenzie Professor of Cell Biology at Harvard Medical School, has been awarded the American Association of Medical Colleges Excellence in Teaching award for his involvement and innovation in the laboratory, in the classroom and across the curriculum at HMS.  

Randy has played a critical role in the major curriculum redesign of the four-year MD program at HMS.  He is ...Read more >>

Latest Research

News - 02/19/2015 - 6:04pm

Danial Lab probes the utility of phospho-BAD BH3 mimicry in restoring functional β-cell mass in diabetes
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Autoimmune destruction of insulin-producing β-cells leaves individuals with type 1 diabetes (T1D) insulin dependent for life. Strategies that replace or regenerate β-cells, including islet transplantation and β-cell generation from non-β-cell precursors are potential therapies in T1D. However, insufficient β-cell proliferation, survival, and insulin secretory response to glucose can limit the benefits of these strategies. As such, molecular pathways or strategies that simultaneously enhance ...Read more >>

News - 12/11/2014 - 9:52pm

Rapoport Lab recapitulates retro-translocation of misfolded proteins with purified components
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Proteins that are translocated into the endoplasmic reticulum (ER) undergo quality control so that only correctly folded proteins are moved on in the secretory pathway. If a protein cannot reach its native folded state, it is ultimately transported back into the cytosol, poly-ubiquitinated, and degraded by the proteasome, a process called ER-associated protein degradation (ERAD). How proteins are retro-translocated across the ER membrane and moved into the cytosol is only poorly understood. ...Read more >>

News - 12/11/2014 - 9:45pm

Rapoport Lab outlines a theoretical model that explains nearly all observed ER morphologies
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The endoplasmic reticulum (ER) is an important membrane-bound organelle in all eukaryotic cells. Depending on cell type and functional state, the ER membrane can adopt different morphologies, including a network of interconnected tubules, and sheets that can contain fenestrations or be stacked on top of each other.  How these different morphologies are generated is unclear. A collaboration of different groups, including the ...Read more >>