• Dr. Kelsey Martin (UCLA) speaks at Neuro-RNA Symposium 2013, organized by Cell Biology postdocs.

  • Left: Actin (green), microtubules (blue), & DNA (red) in a mouse embryonic fibroblast.  Courtesy of A. Lomakin (Danuser lab).
    Right: Endoplasmic reticulum-associated Climp63 (red) & reticulons (green) in mammalian cells.  From Shibata et al. Cell (Rapoport Lab).

  • 2013's newly-minted PhDs from Cell Bio & BBS: Rachel Davidowitz, David Rhee, Joshua Wilson-Grady, M. Rosa Ng, Sinisa Hravtin, & E. Emrah Er. 

  • Left: Larval muscle (red), neurons (green), & nuclei (blue) in Drosophila cells.  Courtesy of A. Sen (Artavanis-Tsakonas Lab).
    Middle: Membrane protein Climp63 (red) & calreticulin (green) in subdomains of the endoplasmic reticulum.  From Shibata et al. Cell (Rapoport Lab).
    Right: Close-up view of Drosophila larval muscle (red), neurons (green), & nuclei (blue).  Courtesy of A. Sen (Artavanis-Tsakonas Lab).

  • Cell Biology faculty members Anders Näär, Tom Rapoport, and John Flanagan at the annual departmental retreat, Cape Cod, Massachusetts.

  • The Neuro-RNA Symposium 2013 organizers: Cell Biology postdocs Nicolas Preitner, Jianhua Shi, Melissa Hancock, and Xinmin Li.

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Latest News

Apr 04, 2014

Mechanism of ferritinophagy revealed by Harper Lab

Autophagy, the process by which proteins and organelles are sequestered in double-membrane structures called autophagosomes and delivered to lysosomes for degradation, is critical in diseases such as cancer and neurodegeneration, but our understanding of how cargo is selected and targeted to autophagosomes is incomplete. The Harper Lab in collaboration with Alec Kimmelman’s lab (DFCI) recently reported in ... Read more

Mar 25, 2014

Danial Lab and collaborators identify a novel class of glucokinase activators

Glucokinase is a glucose-phosphorylating enzyme that regulates insulin release and hepatic metabolism, and its loss-of-function is implicated in the pathogenesis of diabetes. Glucokinase activators (GKAs) are attractive therapeutics in diabetes, however, clinical data indicate that their benefits can be offset by hypoglycemia due to marked allosteric enhancement of the enzyme’s glucose affinity. Recent collaborative studies between the Danial and Walensky laboratories led to the discovery of... Read more

Mar 25, 2014

Danial Lab explores the coordinate regulation of hepatic energy metabolism and gluconeogenesis by the dual-function protein BAD

The homeostatic balance of hepatic glucose utilization, storage and production is exquisitely controlled by hormonal signals and hepatic carbon metabolism during fed and fasted states. How the liver senses extracellular glucose to cue glucose utilization versus production is not fully understood. During short term fasting, glucose is produced by both net glycogenolysis and gluconeogenesis, whereas upon prolonged fasting, glucose is synthesized almost exclusively from gluconeogenesis.... Read more

Feb 28, 2014

Reck-Peterson Lab develops new screening methods to study intracellular transport

Eukaryotic cells transport macromolecules over long distances along the microtubule cytoskeleton using the molecular motors dynein and kinesin. One barrier to understanding how motors transport a vast array of cargos with spatial and temporal specificity is the lack of rapid genetic methods to identify new genes involved in the process. In the March 1 issue of Molecular Biology of the Cell, the... Read more