• Edith Heard 2018 Fawcett Lecture Series

  • Images courtesy of Talley Lambert, PhD (Cell Biology Microscopy Facility)

Recent News & Achievements

Latest Research

Liao lab uncovers the structural basis of RNA-guided DNA degradation by Cascade and Cas3 - Aug 08, 2018

Liao lab uncovers the structural basis of RNA-guided DNA degradation by Cascade and Cas3
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Type I CRISPR-Cas system features a sequential target-searching and degradation process on double-stranded DNA by the RNA-guided Cascade (CRISPR associated complex for antiviral defense) complex and the nuclease-helicase fusion enzyme Cas3, respectively. The Liao lab has used single-particle cryo-electron microscopy (cryo-EM) to generate a near-atomic resolution structure of the Type I-E Cascade/R-loop/Cas3 complex, poised to

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Chouchani lab identifies a new molecular pathway for activation of adipose tissue thermogenesis - Jul 16, 2018

Chouchani lab identifies a new molecular pathway for activation of adipose tissue thermogenesis
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The Chouchani lab has found in their most recent Nature paper that the anti-obesity properties of thermogenic adipose tissues can be activated by the mitochondrial metabolite succinate.  Thermogenic brown and beige adipose tissues can protect against metabolic disease, but require
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Brugge lab discovers that tumor cells use the "wasabi receptor" TRPA1 to survive oxidative stress - May 29, 2018

Brugge lab discovers that tumor cells use the "wasabi receptor" TRPA1 to survive oxidative stress
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The Brugge lab has shown that the calcium channel protein, TRPA1, aids in tumor survival and has proposed targeting this protein as a potential cancer treatment. In a recent publication in Cancer Cell, the Brugge lab shows how TRPA1, normally used by humans as a sensor for environmental irritants such as wasabi or spicy ...Read more >>