• Images courtesy of Talley Lambert, PhD (Cell Biology Microscopy Facility)

  • Pietro De Camilli, MD gives the 2017 Fawcett Lecture

  • The Cell Biology Research Scholars Program is a Harvard University summer internship for undergraduate students with a passion for scientific discovery and fundamental biology.
    Read more and apply ...

Recent Awards & Achievements

Recent Faculty Promotion: Adrian Salic - Jul 21, 2017

Recent Faculty Promotion: Adrian Salic
Adrian Salic

Congratulations to Adrian Salic on his promotion to Professor of Cell Biology!

Adrian uses biochemistry, cell, and chemical biology to elucidate how vertebrate cells send and respond to Hedgehog signals. Two key aspects his lab is currently investigating are the activation of the secreted Hedgehog protein and the regulated proteolysis of Gli, the transcriptional effector of the Hedghog pathway.  ...Read more >>

Latest Research

Liao lab uncovers the structural basis for LPS transport by ABC transporter MsbA - Sep 08, 2017

Liao lab uncovers the structural basis for LPS transport by ABC transporter MsbA
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Lipopolysaccharide (LPS, also known as endotoxin) in Gram-negative bacteria is critical for the bacterial survival and their resistance to antibiotics. As a critical step of LPS biosynthesis, newly produced LPS in the cytoplasmic leaflet of the inner membrane is flipped to the periplasmic leaflet by MsbA, an ATP-binding cassette transporter. In a recent study published in Nature on September 6, the ...Read more >>

Finley lab discovers how red blood cells remodel during terminal differentiation - Aug 24, 2017

Finley lab discovers how red blood cells remodel during terminal differentiation
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The Finley lab, in a recent publication in Science, found that a mutation in the murine Ube2o gene, which encodes an ubiquitin-conjugating enzyme induced during erythropoiesis, results in anemia. Proteomic analysis suggested that UBE2O is a broad-spectrum ubiquitinating enzyme that remodels the erythroid proteome. You can read more about this ...Read more >>

Depolymerase mechanism for a length-dependent microtubule regulator defined by Pellman lab - Aug 23, 2017

Depolymerase mechanism for a length-dependent microtubule regulator defined by Pellman lab
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Proper establishment of the size of intracellular microtubule-based structures, the mitotic spindle or the cilia, is key for their cellular function. One class of mechanisms mediating size control of these intracellular structures utilizes molecular motors as “measuring devices”.  Kinesin-8 motors have a conserved role in regulating the size of microtubule structures, using length-dependent accumulation at the plus-end to preferentially disassemble long microtubules. Despite extensive ...Read more >>