• Cell Biology department at the annual retreat, Cape Cod, Massachusetts - October 12, 2016

  • Images courtesy of Talley Lambert, PhD (Cell Biology Microscopy Facility)

  • Dr. Craig B. Thompson (MSKCC), 2016 Fawcett Lecture Series

Positions Available

Postdoc in Quantitative Biology at Harvard and Dana-Farber

Join Chris Sander’s group as postdoc at Harvard Medical School (Computational Biology Collaboratory at HMS, jointly with the Debora Marks lab) or Dana-Farber Cancer Institute (cBio Center at DFCI), with links to the Broad Institute. We are forming a dynamic group of smart scientists to make scientific discoveries in basic biology and help cure cancer. On computers, in the lab and in collaboration with clinicians. Work with us on:

Perturbation biology and network ...

Recent Awards & Achievements

News - 10/13/2016 - 12:07pm

Steve Liberles named an HHMI Faculty Scholar and also receives NIH Director's Pioneer Award
Steve Liberles

Congratulations to Steve Liberles!  He recently was named an HHMI Faculty Scholar as an early career scientist with great potential.  These scholar awards are funded by the Howard Hughes Medical Institute (HHMI), the Simons Foundation, and the Bill & Melinda Gates Foundation.  For more information, see ...Read more >>

Latest Research

News - 10/18/2016 - 9:57am

Puigserver Lab Finds that Bromodomain Inhibition Rescues Bioenergetic Failures Caused by Mitochondrial Complex I Mutations
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Mutations in mitochondrial proteins (either nuclear or mitochondrial-encoded) cause bioenergetic failures observed in mitochondrial diseases. Rescue of these bioenergetic defects constitutes a feasible strategy to prevent cellular deterioration that leads to cell death. New work from the Puigserver lab, published in Molecular Cell (see also ...Read more >>

News - 09/28/2016 - 12:30pm

Rapoport Lab demonstrates how ER shaping proteins cooperate to generate and maintain a tubular ER network
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How the shape of an organelle is generated is only poorly understood, but is a fundamental question in cell biology. An interesting example is the endoplasmic reticulum (ER) as it consists of morphologically distinct domains. The ER comprises the nuclear envelope and the peripheral ER that consists of tubules connected by three-way junctions into a network, as well as interdispersed sheets. During mitosis, the tubular ER network converts into sheets. Two protein families, the reticulons ( ...Read more >>

News - 09/14/2016 - 1:14pm

Puigserver Lab connects mitochondrial heterogeneity to metastasis
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Metabolic reprogramming in cancer cells is tightly associated with tumor progression but the effect of metabolic regulatory circuits on metastasis processes is poorly understood. New work from the Puigserver lab, published in Nature, reports that mitochondrial heterogeneity driven through the transcriptional coactivator PGC1a defines populations of ...Read more >>