• Edith Heard 2018 Fawcett Lecture Series

  • Images courtesy of Talley Lambert, PhD (Cell Biology Microscopy Facility)

Recent News & Achievements

Latest Research

Yuan Lab discovers molecular link between aging and neurodegeneration - Aug 23, 2018

Yuan Lab discovers molecular link between aging and neurodegeneration
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The Yuan Lab has discovered a molecular link between aging and two major neurodegenerative diseases: amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Their paper in Cell illustrates how the loss of function of the proteins TBK1 and TAK1 lead to neurodegeneration in mice. Aging results in reduced levels of these proteins, ...Read more >>

Liao lab uncovers the structural basis of RNA-guided DNA degradation by Cascade and Cas3 - Aug 08, 2018

Liao lab uncovers the structural basis of RNA-guided DNA degradation by Cascade and Cas3
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Type I CRISPR-Cas system features a sequential target-searching and degradation process on double-stranded DNA by the RNA-guided Cascade (CRISPR associated complex for antiviral defense) complex and the nuclease-helicase fusion enzyme Cas3, respectively. The Liao lab has used single-particle cryo-electron microscopy (cryo-EM) to generate a near-atomic resolution structure of the Type I-E Cascade/R-loop/Cas3 complex, poised to

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Chouchani lab identifies a new molecular pathway for activation of adipose tissue thermogenesis - Jul 16, 2018

Chouchani lab identifies a new molecular pathway for activation of adipose tissue thermogenesis
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The Chouchani lab has found in their most recent Nature paper that the anti-obesity properties of thermogenic adipose tissues can be activated by the mitochondrial metabolite succinate.  Thermogenic brown and beige adipose tissues can protect against metabolic disease, but require
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