Recent Awards & Achievements
Congratulations to Adrian Salic on his promotion to Professor of Cell Biology!
Adrian uses biochemistry, cell, and chemical biology to elucidate how vertebrate cells send and respond to Hedgehog signals. Two key aspects his lab is currently investigating are the activation of the secreted Hedgehog protein and the regulated proteolysis of Gli, the transcriptional effector of the Hedghog pathway. ...Read more >>
Congratulations to Steve Liberles on his promotion to Professor of Cell Biology!
Steve's research focuses on understanding how the brain processes external sensory and internal homeostatic signals that initiate behavioral and physiological responses. Most recently, his lab’s publication in Nature ...Read more >>
Triglyceride (TG) storage in adipose tissue provides the major reservoir for metabolic energy in mammals. During lipolysis, fatty acids (FAs) are hydrolyzed from adipocyte TG stores and transported to other tissues for fuel. For unclear reasons, a large portion of hydrolyzed FAs in adipocytes is re-esterified to TGs in a “futile”, ATP-consuming, energy dissipating cycle. The Farese & Walther lab's recent ...Read more >>
A conserved pathway called “endoplasmic reticulum associated protein degradation (ERAD) is responsible for the disposal of misfolded ER proteins. Previous work from the Rapoport lab indicated that the multi-spanning ubiquitin ligase Hrd1 is a key component of ERAD; Hrd1 allows misfolded luminal and membrane proteins to move from the ER into the cytosol. However, it remained unclear whether Hrd1 forms a protein-conducting channel. In a paper recently published in ...Read more >>
Scientists in the Liao lab and Cornell University have produced near-atomic resolution snapshots of CRISPR that reveal key steps in its mechanism of action. The findings, published in Cell on June 29, provide the structural data necessary for efforts to improve the efficiency and accuracy of CRISPR for biomedical applications. You can read more ...Read more >>