• Edith Heard 2018 Fawcett Lecture Series

  • Images courtesy of Talley Lambert, PhD (Cell Biology Microscopy Facility)

Recent News & Achievements

Latest Research

Chouchani lab identifies a new molecular pathway for activation of adipose tissue thermogenesis - Jul 16, 2018

Chouchani lab identifies a new molecular pathway for activation of adipose tissue thermogenesis
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The Chouchani lab has found in their most recent Nature paper that the anti-obesity properties of thermogenic adipose tissues can be activated by the mitochondrial metabolite succinate.  Thermogenic brown and beige adipose tissues can protect against metabolic disease, but require
...Read more >>

Brugge lab discovers that tumor cells use the "wasabi receptor" TRPA1 to survive oxidative stress - May 29, 2018

Brugge lab discovers that tumor cells use the "wasabi receptor" TRPA1 to survive oxidative stress
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The Brugge lab has shown that the calcium channel protein, TRPA1, aids in tumor survival and has proposed targeting this protein as a potential cancer treatment. In a recent publication in Cancer Cell, the Brugge lab shows how TRPA1, normally used by humans as a sensor for environmental irritants such as wasabi or spicy ...Read more >>

Harper lab develops novel technique to observe ubiquitylation events - May 04, 2018

Harper lab develops novel technique to observe ubiquitylation events

Alban Ordureau, a postdoc in the Harper lab, has developed a proteomics method that allows for the dynamics of PARKIN-dependent mitochondrial ubiquitylation to be followed with unprecedented preision and in a site-specific manner. The approach employed targeted proteomics of ubiquitylation sites in 15 PARKIN targets, allowing digital snapshots of PARKIN activity. This system was used to monitor PARKIN activity in stem cell-derived cortical ...Read more >>