The Kirchhausen Lab is seeking an energetic and highly motivated individual for an opening as Imaging Specialist or Senior Imaging Specialist to start immediately. The ideal candidate would be at the B.Sc./Master's or Engineering level, with imaging experience in wide field, TIRF and/or confocal microscopy and expertise in live and/or single molecule visualization. Proven ability to maintain microscopes and built associated instruments is essential. She/he is an individual interested in ...Read more >>
Recent Awards & Achievements
Cell celebrated its 40th anniversary by revisiting "landmark" Cell publications, an esteemed list that includes six papers from five faculty members: Dan Finley, Wade Harper, Yang Shi, Bruce Spiegelman, and Junying Yuan. One of these papers, Yang Shi's research identifying the first histone demethylase, LSD1, was also honored and showcased as an "Annotated Classic." ...Read more >>
Randy King, the Harry C. McKenzie Professor of Cell Biology at Harvard Medical School, has been awarded the American Association of Medical Colleges Excellence in Teaching award for his involvement and innovation in the laboratory, in the classroom and across the curriculum at HMS.
Proteins that are translocated into the endoplasmic reticulum (ER) undergo quality control so that only correctly folded proteins are moved on in the secretory pathway. If a protein cannot reach its native folded state, it is ultimately transported back into the cytosol, poly-ubiquitinated, and degraded by the proteasome, a process called ER-associated protein degradation (ERAD). How proteins are retro-translocated across the ER membrane and moved into the cytosol is only poorly understood. ...Read more >>
The endoplasmic reticulum (ER) is an important membrane-bound organelle in all eukaryotic cells. Depending on cell type and functional state, the ER membrane can adopt different morphologies, including a network of interconnected tubules, and sheets that can contain fenestrations or be stacked on top of each other. How these different morphologies are generated is unclear. A collaboration of different groups, including the ...Read more >>
Cytoskeletal molecular motors move uni-directionally along their tracks. This poses multiple problems: How do they get to the start of the track? Once there, how do they stay there to capture cargo? A candidate for retaining the microtubule-based motor dynein at the start of its track (microtubule plus ends) is a ubiquitous regulator called Lis1. The Reck-Peterson Lab, in collaboration with the lab of ...Read more >>