• The Don W. Fawcett Lectureship in Cell Biology was established by colleagues in 1988 to attract outstanding scholars to Harvard Medical School. The HMS community is invited to attend the 2015 Fawcett Lecture Series. View program details >>

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News - 03/09/2015 - 4:00pm

Five members of the Cell Bio community profiled in the Dimensions of HMS exhibit
Brugge
Kirchhausen
Van Vactor
Waters
Easley

The Dimensions of Harvard Medical School, in the Transit Gallery of Gordon Hall, is a collection of photographs and profiles that captures a wide representation of the HMS community.  Featured are 5 members of the Cell Biology community: faculty members Joan Brugge, Tomas Kirchhausen, and Davie Van Vactor; Nikon Imaging Center Director Jennifer Waters; and Research Operations Manager Karen Easley. Their profiles are on display until April 7th. ...Read more >>

Latest Research

News - 03/26/2015 - 8:49am

Pellman Lab shows that whole genome duplication can accelerate evolutionary adaptation
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Doubling the compete sets of chromosomes, or tetraploidy, occurs commonly during organismal evolution and also is frequent in disease states, such as cancer.  Theory suggests that increased chromosome sets might promote evolutionary adaptation, especially if many available beneficial mutations are dominant. Whole genome duplications can also alter cell physiology in poorly understood ways.  For example, whole genome duplications often cause genetic instability.  Using in ...Read more >>

News - 03/11/2015 - 2:01pm

Shi Lab uncovers a molecular program that specifies the early neuronal morphology
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Neurons are among the most polarized cells in nature, having emerged more than a half-billion years ago in metazoans to receive, process, and transmit information. The basic instructions to polarize a neuron appear to be intrinsically encoded, but what drives neurons to their extreme morphology is largely unknown. In a recent article in Genes and Development, the ...Read more >>

News - 03/09/2015 - 6:23pm

Moazed Lab uncovers a cellular safeguard that prevents the assembly of inactive Argonaute complexes
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Small RNA molecules are familiar as negative regulators of endogenous protein-coding genes, but their more deeply conserved function is to ensure genomic stability by keeping repetitive and parasitic elements in check. In the fission yeast Schizosaccharomyces pombe, small RNAs accomplish this task by guiding heterochromatin formation at DNA regions flanking the centromere of each chromosome. The small RNA effector complex that targets the heterochromatin machinery to pericentromeric ...Read more >>

News - 03/09/2015 - 2:38pm

Gygi Lab develops methods to identify and quantify thousands of proteins in non-standard model organisms
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Mass spectrometry-based proteomics enables the global identification and quantification of proteins and their posttranslational modifications in complex biological samples. However, proteomic analysis requires a complete and accurate reference set of proteins and is therefore largely restricted to model organisms with sequenced genomes. In collaboration, the Gygi and Kirschner labs demonstrated the feasibility of deep genome-free ...Read more >>