• Dr. Kelsey Martin (UCLA) speaks at Neuro-RNA Symposium 2013, organized by Cell Biology postdocs.

  • Left: Actin (green), microtubules (blue), & DNA (red) in a mouse embryonic fibroblast.  Courtesy of A. Lomakin (Danuser lab).
    Right: Endoplasmic reticulum-associated Climp63 (red) & reticulons (green) in mammalian cells.  From Shibata et al. Cell (Rapoport Lab).

  • 2013's newly-minted PhDs from Cell Bio & BBS: Rachel Davidowitz, David Rhee, Joshua Wilson-Grady, M. Rosa Ng, Sinisa Hravtin, & E. Emrah Er. 

  • Left: Larval muscle (red), neurons (green), & nuclei (blue) in Drosophila cells.  Courtesy of A. Sen (Artavanis-Tsakonas Lab).
    Middle: Membrane protein Climp63 (red) & calreticulin (green) in subdomains of the endoplasmic reticulum.  From Shibata et al. Cell (Rapoport Lab).
    Right: Close-up view of Drosophila larval muscle (red), neurons (green), & nuclei (blue).  Courtesy of A. Sen (Artavanis-Tsakonas Lab).

  • Cell Biology faculty members Anders Näär, Tom Rapoport, and John Flanagan at the annual departmental retreat, Cape Cod, Massachusetts.

  • The Neuro-RNA Symposium 2013 organizers: Cell Biology postdocs Nicolas Preitner, Jianhua Shi, Melissa Hancock, and Xinmin Li.

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Positions Available

Imaging Specialist or Senior Imaging Specialist

The Kirchhausen Lab is seeking an energetic and highly motivated individual for an opening as Imaging Specialist or Senior Imaging Specialist to start immediately. The ideal candidate would be at the B.Sc./Master's or Engineering level, with imaging experience in wide field, TIRF and/or confocal microscopy and expertise in live and/or single molecule visualization. Proven ability to maintain microscopes and built associated instruments is essential. She/he is an individual interested in ...Read more >>

Recent Awards & Achievements

News - 12/02/2014 - 8:29pm

Cell Press designates 6 papers from 5 Cell Biology faculty members as "landmark"
Finley
Harper
Shi
Spiegelman
Yuan

Cell celebrated its 40th anniversary by revisiting "landmark" Cell publications, an esteemed list that includes six papers from five  faculty members: Dan Finley, Wade Harper, Yang Shi, Bruce Spiegelman, and Junying Yuan.  One of these papers, Yang Shi's research identifying the first histone demethylase, LSD1, was also honored and showcased as an "Annotated Classic." ...Read more >>

News - 11/24/2014 - 5:50pm

Randy King recognized for his excellence in teaching
Dr. Randy King

Randy King, the Harry C. McKenzie Professor of Cell Biology at Harvard Medical School, has been awarded the American Association of Medical Colleges Excellence in Teaching award for his involvement and innovation in the laboratory, in the classroom and across the curriculum at HMS.  

Randy has played a critical role in the major curriculum redesign of the four-year MD program at HMS.  He is ...Read more >>

Latest Research

News - 12/11/2014 - 9:52pm

Rapoport Lab recapitulates retro-translocation of misfolded proteins with purified components
[Click to enlarge]

Proteins that are translocated into the endoplasmic reticulum (ER) undergo quality control so that only correctly folded proteins are moved on in the secretory pathway. If a protein cannot reach its native folded state, it is ultimately transported back into the cytosol, poly-ubiquitinated, and degraded by the proteasome, a process called ER-associated protein degradation (ERAD). How proteins are retro-translocated across the ER membrane and moved into the cytosol is only poorly understood. ...Read more >>

News - 12/11/2014 - 9:45pm

Rapoport Lab outlines a theoretical model that explains nearly all observed ER morphologies
[Click to enlarge]

The endoplasmic reticulum (ER) is an important membrane-bound organelle in all eukaryotic cells. Depending on cell type and functional state, the ER membrane can adopt different morphologies, including a network of interconnected tubules, and sheets that can contain fenestrations or be stacked on top of each other.  How these different morphologies are generated is unclear. A collaboration of different groups, including the ...Read more >>

News - 11/13/2014 - 2:48pm

Reck-Peterson Lab reveals that Lis1 works as a molecular wedge to disrupt the dynein mechanochemical cycle
[Click to enlarge]

Cytoskeletal molecular motors move uni-directionally along their tracks. This poses multiple problems: How do they get to the start of the track? Once there, how do they stay there to capture cargo? A candidate for retaining the microtubule-based motor dynein at the start of its track (microtubule plus ends) is a ubiquitous regulator called Lis1. The Reck-Peterson Lab, in collaboration with the lab of ...Read more >>