Biology of the Nucleus and Gene Expression

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Bruce Spiegelman

Bruce Spiegelman
Professor of Cancer Biology (DFCI)
Stanley J. Korsmeyer Professor of Cell Biology and Medicine

Our laboratory is centered on the molecular basis of energy homeostasis and tissue development, using adipogenesis and muscle as the primary model systems. This includes the biochemical mechanisms of metabolic diseases, especially obesity, insulin-resistant diabetes (type 2) and muscle diseases. In addition, we have a major interest in suppressing cancer cell growth by stimulating pathways of altered cell metabolism and DNA repair.

Yang Shi

Yang Shi
Merton Bernfield Professor of Neonatology (BCH)
C.H. Waddington Professor of Pediatrics (HMS/BCH)
Professor of Cell Biology

A major focus of my lab is to understand epigenetic regulation and its role in human diseases. Specifically, we are investigating how histone methylation is dynamically regulated as well as mechanisms involved in the recognition of combinatorial modifications occurring on histone tails that are important for chromatin regulation.

Malcolm Whitman

Malcolm Whitman
Professor of Developmental Biology (HSDM)
Affiliate member of Cell Biology

The Whitman lab is interested in how signals are transduced into highly specific biological responses during embryogenesis, during physiological responses of an organism to stress or damage,  and  during the development of various disease pathologies.

Robin Reed

Robin Reed
Professor of Cell Biology

Our broad goal is to understand the function of human RNA machines, such as the SMN complex, the spliceosome and the TREX complex, in both normal and disease states with current emphasis on Amyotrophic Lateral Sclerosis (ALS) and cancer.

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