New study by Brugge Lab reveals the cellular effects of aging on the mammary gland at high resolution - Jan 14, 2021

Home / News / New study by Brugge Lab reveals the cellular effects of aging on the mammary gland at high resolution - Jan 14, 2021
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Aging of the mammary gland is associated with numerous changes and is linked to higher cancer risk. To better understand these changes, the Brugge lab has performed single-cell transcriptomic analysis on a mouse model to generate a high-resolution atlas of the mammary glands at young and old age. The study, published in Cell Reports, identifies altered cell proportions and gene expression in several cell types, including lesser-known populations in the epithelial and immune compartments. The results highlight patterns of functional decline as well as a shift to a pro-tumorigenic and pro-inflammatory tissue microenvironment, which may contribute to the higher breast cancer risk associated with older age.