Farese/Walther Lab sheds light on a "drop's props" - Nov 18, 2019

Home / News / Farese/Walther Lab sheds light on a "drop's props" - Nov 18, 2019
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Lipid droplets (LDs) store lipids for making cellular membranes and for metabolic energy, but it’s unclear exactly how they’re made. A team led by Robert Farese, Tobias Walther, and Jeeyun Chung (HMS/HSPH) discovered that a complex of lipid droplet assembly factor 1 in interaction with seipin, an endoplasmic reticulum (ER) protein, is the core protein machinery that drives the formation of LDs and determines where they form in the ER. Appearing in Developmental Cell, the work could have implications for common metabolic diseases and industrial applications, such as production or biofuels.