• 2019 Cell Bio Retreat, Cape Cod. We hope to return soon!

  • Images courtesy of Talley Lambert, PhD (Cell Biology Microscopy Facility)

Recent News & Achievements

Dr. Jennifer Waters discusses novel fellowship program - Jan 14, 2021

Dr. Jennifer Waters discusses novel fellowship program

Optical microscopy has become central to progress in many areas of science. At the same time, the complexity of instruments and quantitative imaging experiments has dramatically increased, with many requiring extensive expertise to operate. Microscopy facilities staffed with PhD-level imaging scientists who advise and train researchers on imaging experimental design, the best instruments to use for their experiments, and ...Read more >>

Latest Research

Puigserver Lab identifies that tetracyclines targeting the mitoribosome promote survival and fitness in mitochondrial disease cellular and animal models - Feb 09, 2021

Puigserver Lab identifies that tetracyclines targeting the mitoribosome promote survival and fitness in mitochondrial disease cellular and animal models
[Click to enlarge]

Mitoribosome translation synthesizes proteins that are inserted into the inner mitochondrial membrane and assembled into functional respiratory complexes. Mitochondrial disease mutations interfere with this process and produce severe cellular damage and associated pathologies. However, the mechanisms underlying this cellular deterioration and how it can be repaired are largely unknown. In a new study published in ...Read more >>

Rapoport lab reveals the mechanism of curvature generation by ER-shaping proteins - Jan 27, 2021

Rapoport lab reveals the mechanism of curvature generation by ER-shaping proteins
[Click to enlarge]

All cellular organelles have characteristic shapes. The endoplasmic reticulum (ER) is particularly intriguing, as it contains a network of interconnected tubules. The tubules have high membrane curvature in cross-section, generated by the reticulon and REEP protein families, but how these proteins cause curvature is poorly understood. In a new study published in Nature Communications, the ...Read more >>

New study by Brugge Lab reveals the cellular effects of aging on the mammary gland at high resolution - Jan 14, 2021

New study by Brugge Lab reveals the cellular effects of aging on the mammary gland at high resolution
[Click to enlarge]
Aging of the mammary gland is associated with numerous changes and is linked to higher cancer risk. To better understand these changes, the Brugge lab has performed single-cell transcriptomic analysis on a mouse model to generate a high-resolution atlas of the mammary glands at young and old age. The study, published in Cell
...Read more >>