• 2019 Cell Bio Retreat, Cape Cod. We hope to return soon!

  • Images courtesy of Talley Lambert, PhD (Cell Biology Microscopy Facility)

Recent News & Achievements

Dr. John Flanagan selected for the 2020 Barbara J. McNeil Faculty Award - Oct 26, 2020

Dr. John Flanagan selected for the 2020 Barbara J. McNeil Faculty Award

Dr. John Flanagan has been selected as a recipient of the 2020 Barbara J. McNeil Faculty Award for exceptional institutional service to HMS/HSDM. This prestigious award recognizes faculty who are actively engaged in supporting the missions of Harvard Medical School and Harvard School of Dental Medicine. John has played an extensive ...Read more >>

Latest Research

The Chouchani Lab, led by BBS student Anita Reddy and post-doc Luiz Bozi, describe a pH-sensing metabolite signal that regulates the muscle response to exercise. - Sep 22, 2020

The Chouchani Lab, led by BBS student Anita Reddy and post-doc Luiz Bozi, describe a pH-sensing metabolite signal that regulates the muscle response to exercise.
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Using small molecule mass spectrometry approaches the Chouchani Lab team show that during exercise, mouse and human muscle selectively release the mitochondrial metabolite succinate into extracellular fluids. This release is unusual since succinate is a dicarboxylate, which should remain trapped in the cell. But during muscle cell acidification that occurs upon exercise, succinate becomes protonated and transformed to a ...Read more >>