The overall goal of our work is to solve biological problems using quantitative methods from bioinformatics, statistical physics, data sciences, statistics, computer science, and mathematics. We apply these computational methods to build predictive network models of molecular and cell-cell interactions, to support cancer precision medicine, and to make discoveries in structural and evolutionary biology.
We aim to understand the molecular mechanisms that regulate protein biogenesis and quality control pathways with approaches utilizing biochemistry, structural biology, and cell biology. Specific interests focus on processes that occur on ribosomes and at cellular membranes.
We use high-resolution electron microscopy to study the structure and function of membrane proteins and other macromolecular complexes.
Our research focuses on the processes that mediate and regulate the movement of membrane proteins throughout cells.