Our research focuses on the processes that mediate and regulate the movement of membrane proteins throughout cells.
Chemistry and Proteomics
We study biochemical and cellular mechanisms involved in signal transduction through the Hedgehog signaling pathway. We also develop and apply new chemical technologies to study the cell biology of lipids.
Our laboratory studies the functions and mechanisms of the ubiquitin-proteasome and autophagy systems in cellular signaling and neurodegeneration using proteomic, genetic and biochemical approaches.
The primary focus of our laboratory is to delineate cellular energy and nutrient sensing pathways, including metabolic checkpoints that integrate cellular survival and bioenergetics.
Our lab integrates chemical and cell biological approaches to study cell division and chromosome segregation.
The Farese & Walther Lab determines the mechanisms how cells regulate the abundance of lipids, how they store lipids to buffer fluctuation in their availability and how these processes function in membrane biology and cell physiology.
Our research focuses on deciphering molecular mechanisms that drive metabolic disease, and using this information to develop targeted therapeutic strategies. Mitochondria are critical hubs for metabolic signalling, and their dysfunction is key in the pathology of metabolic disease. We combine mass spectrometry and targeted pharmacological approaches in vivo to understand how mitochondrial redox metabolism controls physiology in clinically informative mouse models of obesity and diabetes.
Our laboratory determines the mechanisms how cells regulate the abundance of lipids, how they store lipids to buffer fluctuation in their availability and how these processes function in membrane biology and cell physiology.
My lab studies internal and external sensory systems, such as olfaction, taste, and internal senses mediated by the vagus nerve. We seek to unravel the molecular logic of sensory systems- from stimulus detection in the periphery to the orchestration of behavioral and physiological responses.
Our laboratory is interested in nutrient sensing in mammalian cells and how it connects to the transcriptional machinery to control gene metabolic regulatory networks.