Chemistry and Proteomics

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Edward Chouchani

Assistant Professor of Cancer Biology (DFCI)
Assistant Professor of Cell Biology

Our research focuses on deciphering molecular mechanisms that drive metabolic disease, and using this information to develop targeted therapeutic strategies.  Mitochondria are critical hubs for metabolic signalling, and their dysfunction is key in the pathology of metabolic disease.  We combine mass spectrometry and targeted pharmacological approaches in vivo to understand how mitochondrial redox metabolism controls physiology in clinically informative mouse models of obesity and diabetes.

Robert V. Farese, Jr.

Bob Farese
Professor of Genetics and Complex Diseases (HSPH)
Professor of Cell Biology

The Farese & Walther Lab determines the mechanisms how cells regulate the abundance of lipids, how they store lipids to buffer fluctuation in their availability and how these processes function in membrane biology and cell physiology.

Tobias Walther

Tobias Walther, Ph.D.
Professor of Genetics and Complex Diseases (HSPH)
Professor of Cell Biology
HHMI Investigator

Our laboratory determines the mechanisms how cells regulate the abundance of lipids, how they store lipids to buffer fluctuation in their availability and how these processes function in membrane biology and cell physiology.

Adrian Salic

Adrian Salic
Associate Professor of Cell Biology

We study biochemical and cellular mechanisms involved in signal transduction through the Hedgehog signaling pathway. We also develop and apply new chemical technologies to study the cell biology of lipids.

Pere Puigserver

Pere Puigserver
Professor of Cancer Biology (DFCI)
Professor of Cell Biology

Our laboratory is interested in nutrient sensing in mammalian cells and how it connects to the transcriptional machinery to control gene metabolic regulatory networks.

Stephen Liberles

Professor of Cell Biology
Member: Harvard Program in Neuroscience

My lab studies internal and external sensory systems, such as olfaction, taste, and internal senses mediated by the vagus nerve. We seek to unravel the molecular logic of sensory systems- from stimulus detection in the periphery to the orchestration of behavioral and physiological responses.

Tomas Kirchhausen

Tomas Kirchhausen
Springer Family Chair (BCH)
Senior Investigator, Program in Cellular and Molecular Medicine (BCH)
Professor of Cell Biology

Our research focuses on the processes that mediate and regulate the movement of membrane proteins throughout cells.

Wade Harper

Wade Harper
Chair & Professor of Cell Biology
Bert and Natalie Vallee Professor of Molecular Pathology

Our laboratory studies the functions and mechanisms of the ubiquitin-proteasome system in cell cycle and checkpoint control using proteomic, genetic and biochemical approaches.

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