My lab studies internal and external sensory systems, such as olfaction, taste, and internal senses mediated by the vagus nerve. We seek to unravel the molecular logic of sensory systems- from stimulus detection in the periphery to the orchestration of behavioral and physiological responses.
The Haigis laboratory focuses on the molecular regulation of mitochondrial functions during aging and age-related disease. Our goal is to investigate how pathways that control aging, such as sirtuins, impact mitochondrial fuel utilization, bioenergetics and signaling. To achieve these objectives, we take a multidisciplinary approach that employs biochemical, cellular, and mouse modeling experiments to systematically dissect the mitochondrial pathways of interest.
Our laboratory studies the functions and mechanisms of the ubiquitin-proteasome system in cell cycle and checkpoint control using proteomic, genetic and biochemical approaches.
Our laboratory is presently studying the regulation and mechanisms of protein breakdown in animal and bacterial cells.
We study how cell-cell signaling molecules set up spatial pattern, particularly in the development and regeneration of connections in the nervous system.
Our laboratory is investigating the cellular processes and pathways that are involved in normal morphogenesis of epithelial tissues as well as those involved in the initiation and progression of epithelial tumors.
Using molecular and genetic approaches, we are examining how various signals are integrated in undifferentiated cells in order to dictate cell fates and ultimately influence morphogenesis. Our main experimental system is Drosophila, but we are interested in exploiting this system as a tool to explore human biology and understand the underlying mechanisms of pathologies such as cancer.