Cellular Signaling

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Adrian Salic

Adrian Salic
Professor of Cell Biology

We study biochemical and cellular mechanisms involved in signal transduction through the Hedgehog signaling pathway. We also develop and apply new chemical technologies to study the cell biology of lipids.

Chris Sander

Professor in Residence of Cell Biology

The overall goal of our work is to solve biological problems using quantitative methods from bioinformatics, statistical physics, data sciences, statistics, computer science, and mathematics. We apply these computational methods to build predictive network models of molecular and cell-cell interactions, to support cancer precision medicine, and to make discoveries in structural and evolutionary biology.

Edward Chouchani

Assistant Professor of Cancer Biology (DFCI)
Assistant Professor of Cell Biology

Our research focuses on deciphering molecular mechanisms that drive metabolic disease, and using this information to develop targeted therapeutic strategies.  Mitochondria are critical hubs for metabolic signalling, and their dysfunction is key in the pathology of metabolic disease.  We combine mass spectrometry and targeted pharmacological approaches in vivo to understand how mitochondrial redox metabolism controls physiology in clinically informative mouse models of obesity and diabetes.

Robert V. Farese, Jr.

Bob Farese
Professor of Genetics and Complex Diseases (HSPH)
Professor of Cell Biology

The Farese & Walther Lab determines the mechanisms how cells regulate the abundance of lipids, how they store lipids to buffer fluctuation in their availability and how these processes function in membrane biology and cell physiology.

Tobias Walther

Tobias Walther, Ph.D.
Professor of Genetics and Complex Diseases (HSPH)
Professor of Cell Biology
HHMI Investigator

Our laboratory determines the mechanisms how cells regulate the abundance of lipids, how they store lipids to buffer fluctuation in their availability and how these processes function in membrane biology and cell physiology.

Junying Yuan

Junying Yuan
Elizabeth D. Hay Professor of Cell Biology

The research in Yuan lab is aimed at elucidation of the molecular mechanisms regulating cell death under physiological and pathological conditions.

Malcolm Whitman

Malcolm Whitman
Professor of Developmental Biology (HSDM)
Affiliate member of Cell Biology

The Whitman lab is interested in how signals are transduced into highly specific biological responses during embryogenesis, during physiological responses of an organism to stress or damage,  and  during the development of various disease pathologies.

David Van Vactor

David Van Vactor
Professor of Cell Biology
Director of the Developmental and Regenerative Biology (DRB) Graduate Program

My research interests are focused on the molecular mechanisms that guide neuronal growth cones through the developing embryo to reach and select their appropriate synaptic targets.

Yang Shi

Yang Shi
Merton Bernfield Professor of Neonatology (BCH)
Professor of Cell Biology

A major focus of my lab is to understand epigenetic regulation and its role in human diseases. Specifically, we are investigating how histone methylation is dynamically regulated as well as mechanisms involved in the recognition of combinatorial modifications occurring on histone tails that are important for chromatin regulation.

Pere Puigserver

Pere Puigserver
Professor of Cancer Biology (DFCI)
Professor of Cell Biology

Our laboratory is interested in nutrient sensing in mammalian cells and how it connects to the transcriptional machinery to control gene metabolic regulatory networks.

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