Cellular Physiology

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Stephen Liberles

Professor of Cell Biology
Member: Harvard Program in Neuroscience

My lab studies internal and external sensory systems, such as olfaction, taste, and internal senses mediated by the vagus nerve. We seek to unravel the molecular logic of sensory systems- from stimulus detection in the periphery to the orchestration of behavioral and physiological responses.

Tobias Walther

Tobias Walther, Ph.D.
Professor of Genetics and Complex Diseases (HSPH)
Professor of Cell Biology
HHMI Investigator

Our laboratory determines the mechanisms how cells regulate the abundance of lipids, how they store lipids to buffer fluctuation in their availability and how these processes function in membrane biology and cell physiology.

Robert V. Farese, Jr.

Bob Farese
Professor of Genetics and Complex Diseases (HSPH)
Professor of Cell Biology

The Farese & Walther Lab determines the mechanisms how cells regulate the abundance of lipids, how they store lipids to buffer fluctuation in their availability and how these processes function in membrane biology and cell physiology.

Edward Chouchani

Assistant Professor of Cancer Biology (DFCI)
Assistant Professor of Cell Biology

Our research focuses on deciphering molecular mechanisms that drive metabolic disease, and using this information to develop targeted therapeutic strategies.  Mitochondria are critical hubs for metabolic signalling, and their dysfunction is key in the pathology of metabolic disease.  We combine mass spectrometry and targeted pharmacological approaches in vivo to understand how mitochondrial redox metabolism controls physiology in clinically informative mouse models of obesity and diabetes.

Pere Puigserver

Pere Puigserver
Professor of Cancer Biology (DFCI)
Professor of Cell Biology

Our laboratory is interested in nutrient sensing in mammalian cells and how it connects to the transcriptional machinery to control gene metabolic regulatory networks.

Marcia Haigis

Associate Professor of Cell Biology

The Haigis laboratory focuses on the molecular regulation of mitochondrial functions during aging and age-related disease. Our goal is to investigate how pathways that control aging, such as sirtuins, impact mitochondrial fuel utilization, bioenergetics and signaling. To achieve these objectives, we take a multidisciplinary approach that employs biochemical, cellular, and mouse modeling experiments to systematically dissect the mitochondrial pathways of interest.

Nika Danial

Nika Danial
Associate Professor of Cancer Biology (DFCI)
Affiliate member of Cell Biology

The primary focus of our laboratory is to delineate cellular energy and nutrient sensing pathways, including metabolic checkpoints that integrate cellular survival and bioenergetics.

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