Our research focuses on deciphering molecular mechanisms that drive metabolic disease, and using this information to develop targeted therapeutic strategies. Mitochondria are critical hubs for metabolic signalling, and their dysfunction is key in the pathology of metabolic disease. We combine mass spectrometry and targeted pharmacological approaches in vivo to understand how mitochondrial redox metabolism controls physiology in clinically informative mouse models of obesity and diabetes.
The Farese & Walther Lab determines the mechanisms how cells regulate the abundance of lipids, how they store lipids to buffer fluctuation in their availability and how these processes function in membrane biology and cell physiology.
Our laboratory determines the mechanisms how cells regulate the abundance of lipids, how they store lipids to buffer fluctuation in their availability and how these processes function in membrane biology and cell physiology.
Our laboratory is interested in nutrient sensing in mammalian cells and how it connects to the transcriptional machinery to control gene metabolic regulatory networks.
My lab studies internal and external sensory systems, such as olfaction, taste, and internal senses mediated by the vagus nerve. We seek to unravel the molecular logic of sensory systems- from stimulus detection in the periphery to the orchestration of behavioral and physiological responses.
Our lab integrates chemical and cell biologal approaches to study cell division and chromosome segregation.
The Haigis laboratory focuses on the molecular regulation of mitochondrial functions during aging and age-related disease. Our goal is to investigate how pathways that control aging, such as sirtuins, impact mitochondrial fuel utilization, bioenergetics and signaling. To achieve these objectives, we take a multidisciplinary approach that employs biochemical, cellular, and mouse modeling experiments to systematically dissect the mitochondrial pathways of interest.
The primary focus of our laboratory is to delineate cellular energy and nutrient sensing pathways, including metabolic checkpoints that integrate cellular survival and bioenergetics.
Our laboratory is presently studying the regulation and mechanisms of protein breakdown in animal and bacterial cells.