Our research focuses on the processes that mediate and regulate the movement of membrane proteins throughout cells.
Cell Cycle and Proliferation
Our laboratory studies the functions and mechanisms of the ubiquitin-proteasome and autophagy systems in cellular signaling and neurodegeneration using proteomic, genetic and biochemical approaches.
Our lab integrates chemical and cell biological approaches to study cell division and chromosome segregation.
A major focus of my lab is to understand epigenetic regulation and its role in human diseases. Specifically, we are investigating how histone methylation is dynamically regulated as well as mechanisms involved in the recognition of combinatorial modifications occurring on histone tails that are important for chromatin regulation.
The Haigis laboratory focuses on the molecular regulation of mitochondrial functions during aging and age-related disease. Our goal is to investigate how pathways that control aging, such as sirtuins, impact mitochondrial fuel utilization, bioenergetics and signaling. To achieve these objectives, we take a multidisciplinary approach that employs biochemical, cellular, and mouse modeling experiments to systematically dissect the mitochondrial pathways of interest.
We are interested in the ubiquitin-proteasome pathway and related regulatory systems. Specific topics include the mechanism of the proteasome, ubiquitin-like proteins, antizyme, and nonproteolytic functions of ubiquitination.
Our laboratory is investigating the cellular processes and pathways that are involved in normal morphogenesis of epithelial tissues as well as those involved in the initiation and progression of epithelial tumors.