Using molecular and genetic approaches, we are examining how various signals are integrated in undifferentiated cells in order to dictate cell fates and ultimately influence morphogenesis. Our main experimental system is Drosophila, but we are interested in exploiting this system as a tool to explore human biology and understand the underlying mechanisms of pathologies such as cancer.
Our laboratory is investigating the cellular processes and pathways that are involved in normal morphogenesis of epithelial tissues as well as those involved in the initiation and progression of epithelial tumors.
Our research focuses on deciphering molecular mechanisms that drive metabolic disease, and using this information to develop targeted therapeutic strategies. Mitochondria are critical hubs for metabolic signalling, and their dysfunction is key in the pathology of metabolic disease. We combine mass spectrometry and targeted pharmacological approaches in vivo to understand how mitochondrial redox metabolism controls physiology in clinically informative mouse models of obesity and diabetes.
The primary focus of our laboratory is to delineate cellular energy and nutrient sensing pathways, including metabolic checkpoints that integrate cellular survival and bioenergetics.
The Farese & Walther Lab determines the mechanisms how cells regulate the abundance of lipids, how they store lipids to buffer fluctuation in their availability and how these processes function in membrane biology and cell physiology.
We are interested in the ubiquitin-proteasome pathway and related regulatory systems. Specific topics include the mechanism of the proteasome, ubiquitin-like proteins, antizyme, and nonproteolytic functions of ubiquitination.
We study how cell-cell signaling molecules set up spatial pattern, particularly in the development and regeneration of connections in the nervous system.
Our laboratory is presently studying the regulation and mechanisms of protein breakdown in animal and bacterial cells.
We are interested in developing and applying new technologies in the fields of mass spectrometry and proteomics.
The Haigis laboratory focuses on the molecular regulation of mitochondrial functions during aging and age-related disease. Our goal is to investigate how pathways that control aging, such as sirtuins, impact mitochondrial fuel utilization, bioenergetics and signaling. To achieve these objectives, we take a multidisciplinary approach that employs biochemical, cellular, and mouse modeling experiments to systematically dissect the mitochondrial pathways of interest.
Our laboratory studies the functions and mechanisms of the ubiquitin-proteasome and autophagy systems in cellular signaling and neurodegeneration using proteomic, genetic and biochemical approaches.
Our lab integrates chemical and cell biological approaches to study cell division and chromosome segregation.
Our research focuses on the processes that mediate and regulate the movement of membrane proteins throughout cells.
We use high-resolution electron microscopy to study the structure and function of membrane proteins and other macromolecular complexes.
My lab studies internal and external sensory systems, such as olfaction, taste, and internal senses mediated by the vagus nerve. We seek to unravel the molecular logic of sensory systems- from stimulus detection in the periphery to the orchestration of behavioral and physiological responses.
We study how protein- and RNA-based mechanisms mediate the formation and propagation of epigenetic chromatin domains.
Our laboratory studies tissue and organ morphogenesis.
Our laboratory works on cell biology topics in two areas: cytoskeletal dynamics and the control of genome stability. Our approaches include genetics, functional genomics, biochemistry and live cell imaging. Ongoing projects use both yeast and animal cell systems.
Our laboratory is interested in nutrient sensing in mammalian cells and how it connects to the transcriptional machinery to control gene metabolic regulatory networks.
We are interested in the molecular mechanisms by which proteins are transported across or are inserted into the endoplasmic reticulum (ER) membrane. We have dissected both cotranslational protein translocation in mammals and posttranslational translocation in yeast using a combination of biochemical approaches.
Our broad goal is to understand the function of human RNA machines, such as the SMN complex, the spliceosome and the TREX complex, in both normal and disease states with current emphasis on Amyotrophic Lateral Sclerosis (ALS) and cancer.
We study biochemical and cellular mechanisms involved in signal transduction through the Hedgehog signaling pathway. We also develop and apply new chemical technologies to study the cell biology of lipids.
The overall goal of our work is to solve biological problems using quantitative methods from bioinformatics, statistical physics, data sciences, statistics, computer science, and mathematics. We apply these computational methods to build predictive network models of molecular and cell-cell interactions, to support cancer precision medicine, and to make discoveries in structural and evolutionary biology.
We aim to understand the molecular mechanisms that regulate protein biogenesis and quality control pathways with approaches utilizing biochemistry, structural biology, and cell biology. Specific interests focus on processes that occur on ribosomes and at cellular membranes.
A major focus of my lab is to understand epigenetic regulation and its role in human diseases. Specifically, we are investigating how histone methylation is dynamically regulated as well as mechanisms involved in the recognition of combinatorial modifications occurring on histone tails that are important for chromatin regulation.
Our laboratory is centered on the molecular basis of energy homeostasis and tissue development, using adipogenesis and muscle as the primary model systems. This includes the biochemical mechanisms of metabolic diseases, especially obesity, insulin-resistant diabetes (type 2) and muscle diseases. In addition, we have a major interest in suppressing cancer cell growth by stimulating pathways of altered cell metabolism and DNA repair.
My research interests are focused on the molecular mechanisms that guide neuronal growth cones through the developing embryo to reach and select their appropriate synaptic targets.
Our laboratory determines the mechanisms how cells regulate the abundance of lipids, how they store lipids to buffer fluctuation in their availability and how these processes function in membrane biology and cell physiology.
The Whitman lab is interested in how signals are transduced into highly specific biological responses during embryogenesis, during physiological responses of an organism to stress or damage, and during the development of various disease pathologies.
The research in Yuan lab is aimed at elucidation of the molecular mechanisms regulating cell death under physiological and pathological conditions.